6J3B: Crystal structure of human DHODH in complex with inhibitor 1289

PDB ID: 6J3BDownload
MMDB ID: 178639
PDB Deposition Date: 2019/1/4
Updated in MMDB: 2019/08
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6J3B: monomeric; determined by author and by software (PISA)
Molecular Components in 6J3B
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (23 molecules)
1
6
SULFATE IONSULFATE ION
2
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
3
1
OROTIC ACIDOROTIC ACID
4
1
(6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one(6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one
5
1
LAURYL DIMETHYLAMINE-N-OXIDELAURYL DIMETHYLAMINE-N-OXIDE
6
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
7
6
ACETATE IONACETATE ION
8
3
CHLORIDE IONCHLORIDE ION
9
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303