6IW7: structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease

PDB ID: 6IW7Download
MMDB ID: 253177
PDB Deposition Date: 2018/12/4
Updated in MMDB: 2025/05
Experimental Method:
x-ray diffraction
Resolution: 2.69212  Å
Source Organism:
Similar Structures:
Biological Unit for 6IW7: dimeric; determined by author and by software (PISA)
Molecular Components in 6IW7
Label Count Molecule
Proteins (2 molecules)
1
Atp-dependent CLP Protease Proteolytic Subunit 2
Molecule annotation
1
Atp-dependent CLP Protease Proteolytic Subunit 1
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
(2S)-2-benzamido-4-methyl-pentanoic acid(2S)-2-benzamido-4-methyl-pentanoic acid
2
2
LEUCINELEUCINE
3
2
4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303