6IG8: Crystal structure of CSF-1R kinase domain with a small molecular inhibitor, JTE-952

PDB ID: 6IG8Download
MMDB ID: 178170
PDB Deposition Date: 2018/9/25
Updated in MMDB: 2019/08
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 6IG8: monomeric; determined by author
Molecular Components in 6IG8
Label Count Molecule
Protein (1 molecule)
1
Macrophage Colony-stimulating Factor 1 Receptor
(Gene symbol: CSF1R)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
1
GLYCEROLGLYCEROL
3
1
(3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2S)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone(3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2S)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303