6IC5: Human cathepsin-C in complex with dipeptidyl cyclopropyl nitrile inhibitor 2

PDB ID: 6IC5Download
MMDB ID: 174619
PDB Deposition Date: 2018/12/2
Updated in MMDB: 2019/06
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 6IC5: dodecameric; determined by author and by software (PISA)
Molecular Components in 6IC5
Label Count Molecule
Proteins (12 molecules)
4
Dipeptidyl Peptidase 1
(Gene symbol: CTSC)
Molecule annotation
4
Dipeptidyl Peptidase 1
(Gene symbol: CTSC)
Molecule annotation
4
Dipeptidyl Peptidase 1
(Gene symbol: CTSC)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
16
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
4
CHLORIDE IONCHLORIDE ION
3
4
(2~{S})-2-azanyl-~{N}-[(1~{R},2~{R})-1-(iminomethyl)-2-[4-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]phenyl]cyclopropyl]-3-thiophen-2-yl-propanamide(2~{S})-2-azanyl-~{N}-[(1~{R},2~{R})-1-(iminomethyl)-2-[4-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]phenyl]cyclopropyl]-3-thiophen-2-yl-propanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303