6IBT: Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737

PDB ID: 6IBTDownload
MMDB ID: 180250
PDB Deposition Date: 2018/11/30
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 2.04  Å
Source Organism:
Similar Structures:
Biological Unit for 6IBT: dimeric; determined by software (PISA)
Molecular Components in 6IBT
Label Count Molecule
Proteins (2 molecules)
2
Alpha-galactosidase a
(Gene symbol: GLA)
Molecule annotation
Chemicals and Non-standard biopolymers (38 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
3
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
6
2
(1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol(1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
7
5
SULFATE IONSULFATE ION
8
6
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303