6IBK: Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfamidate ME763

PDB ID: 6IBKDownload
MMDB ID: 180247
PDB Deposition Date: 2018/11/30
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 6IBK: dimeric; determined by author and by software (PISA)
Molecular Components in 6IBK
Label Count Molecule
Proteins (2 molecules)
2
Alpha-galactosidase a
(Gene symbol: GLA)
Molecule annotation
Chemicals and Non-standard biopolymers (50 molecules)
1
11
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
3
alpha-D-mannopyranosealpha-D-mannopyranose
4
3
ACETATE IONACETATE ION
5
11
SULFATE IONSULFATE ION
6
12
1,2-ETHANEDIOL1,2-ETHANEDIOL
7
2
(3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol(3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol
8
5
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303