6I99: Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24

PDB ID: 6I99Download
MMDB ID: 187917
PDB Deposition Date: 2018/11/22
Updated in MMDB: 2020/05
Experimental Method:
x-ray diffraction
Resolution: 2.001  Å
Source Organism:
Similar Structures:
Biological Unit for 6I99: monomeric; determined by author
Molecular Components in 6I99
Label Count Molecule
Protein (1 molecule)
1
Cytoplasmic Tyrosine-protein Kinase BMX
(Gene symbol: BMX)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303