6I29: X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution

PDB ID: 6I29Download
MMDB ID: 181396
PDB Deposition Date: 2018/11/1
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Similar Structures:
Biological Unit for 6I29: dimeric; determined by software (PISA)
Molecular Components in 6I29
Label Count Molecule
Proteins (2 molecules)
2
Human E3 Ubiquitin-protein Ligase Mdm2
(Gene symbol: MDM2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303