6HWO: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335

PDB ID: 6HWODownload
MMDB ID: 177648
PDB Deposition Date: 2018/10/12
Updated in MMDB: 2019/09
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 6HWO: monomeric; determined by author
Molecular Components in 6HWO
Label Count Molecule
Protein (1 molecule)
1
Camp-specific 3',5'-cyclic Phosphodiesterase 4D
(Gene symbol: PDE4D)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
20
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
3
1
ZINC IONZINC ION
4
1
3-[5-[(4aR,8aS)-4-OXIDANYLIDENE-3-PROPAN-2-YL-4a,5,8,8a-TETRAHYDROPHTHALAZIN-1-YL]-2-METHOXY-PHENYL]-N-(PHENYLMETHYL)PROP-2-YNAMIDE3-[5-[(4aR,8aS)-4-OXIDANYLIDENE-3-PROPAN-2-YL-4a,5,8,8a-TETRAHYDROPHTHALAZIN-1-YL]-2-METHOXY-PHENYL]-N-(PHENYLMETHYL)PROP-2-YNAMIDE
5
1
MAGNESIUM IONMAGNESIUM ION
6
1
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303