6HHC: Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI

PDB ID: 6HHCDownload
MMDB ID: 179247
PDB Deposition Date: 2018/8/27
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 6HHC: trimeric; determined by author and by software (PISA)
Molecular Components in 6HHC
Label Count Molecule
Proteins (3 molecules)
1
Fxia Antibody FAB Light Chain
Molecule annotation
1
Fxia Antibody FAB Heavy Chain
Molecule annotation
1
Coagulation Factor XI
(Gene symbol: F11)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
3
SULFATE IONSULFATE ION
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303