6H50: Crystal structure of human KDM5B in complex with compound 34a

PDB ID: 6H50Download
MMDB ID: 176043
PDB Deposition Date: 2018/7/23
Updated in MMDB: 2019/06
Experimental Method:
x-ray diffraction
Resolution: 2.19  Å
Source Organism:
Similar Structures:
Biological Unit for 6H50: monomeric; determined by author and by software (PISA)
Molecular Components in 6H50
Label Count Molecule
Protein (1 molecule)
1
Lysine-specific Demethylase 5b,lysine-specific Demethylase 5B
(Gene symbol: KDM5B)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
ZINC IONZINC ION
2
2
MANGANESE (II) IONMANGANESE (II) ION
3
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
PHOSPHATE IONPHOSPHATE ION
5
1
8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one
6
5
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303