6E6E: DGY-06-116, a novel and selective covalent inhibitor of SRC kinase

PDB ID: 6E6EDownload
MMDB ID: 177882
PDB Deposition Date: 2018/7/24
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 6E6E: monomeric; determined by author and by software (PISA)
Molecular Components in 6E6E
Label Count Molecule
Protein (1 molecule)
1
Proto-oncogene Tyrosine-protein Kinase SRC
(Gene symbol: SRC)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamideN-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303