6E3E: Structure of RORgt in complex with a novel inverse agonist

PDB ID: 6E3EDownload
MMDB ID: 177421
PDB Deposition Date: 2018/7/13
Updated in MMDB: 2020/07
Experimental Method:
x-ray diffraction
Resolution: 2.47  Å
Source Organism:
Similar Structures:
Biological Unit for 6E3E: monomeric; determined by author and by software (PISA)
Molecular Components in 6E3E
Label Count Molecule
Protein (1 molecule)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
SULFATE IONSULFATE ION
2
1
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
3
1
5-[(5R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-5-oxopentanoic acid5-[(5R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-5-oxopentanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303