6DDI: Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue

PDB ID: 6DDIDownload
MMDB ID: 181194
PDB Deposition Date: 2018/5/10
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6DDI: dimeric; determined by author and by software (PISA)
Molecular Components in 6DDI
Label Count Molecule
Proteins (2 molecules)
2
Bromodomain-containing Protein 2
(Gene symbol: BRD2)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
3
4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile
2
1
SULFATE IONSULFATE ION
3
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
methanesulfonic acidmethanesulfonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303