6D0V: Tryptophan synthase Q114A mutant in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate at the beta site, and cesium ion at the metal coordination site

PDB ID: 6D0VDownload
MMDB ID: 174301
PDB Deposition Date: 2018/4/11
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.64  Å
Source Organism:
Similar Structures:
Biological Unit for 6D0V: tetrameric; determined by author and by software (PISA)
Molecular Components in 6D0V
Label Count Molecule
Proteins (4 molecules)
2
Tryptophan Synthase Alpha Chain
(Gene symbol: trpA)
Molecule annotation
2
Tryptophan Synthase Beta Chain
(Gene symbol: trpB)
Molecule annotation
Chemicals and Non-standard biopolymers (72 molecules)
1
32
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
2
8
CHLORIDE IONCHLORIDE ION
3
2
2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE
4
16
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid
6
6
CESIUM IONCESIUM ION
7
2
SERINESERINE
8
4
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303