6AGX: The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold

PDB ID: 6AGXDownload
MMDB ID: 178590
PDB Deposition Date: 2018/8/15
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.95  Å
Source Organism:
Similar Structures:
Biological Unit for 6AGX: dimeric; determined by author and by software (PISA)
Molecular Components in 6AGX
Label Count Molecule
Proteins (2 molecules)
2
Fibroblast Growth Factor Receptor 2
(Gene symbol: FGFR2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1H-imidazol-1-yl]acetateethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1H-imidazol-1-yl]acetate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303