5X24: Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules

PDB ID: 5X24Download
MMDB ID: 155435
PDB Deposition Date: 2017/1/30
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.48  Å
Source Organism:
Similar Structures:
Biological Unit for 5X24: monomeric; determined by author and by software (PISA)
Molecular Components in 5X24
Label Count Molecule
Protein (1 molecule)
1
Cytochrome P450 2C9
(Gene symbol: CYP2C9)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
2
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
3
1
PHOSPHATE IONPHOSPHATE ION
4
1
POTASSIUM IONPOTASSIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303