5W5O: Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases

PDB ID: 5W5ODownload
MMDB ID: 155415
PDB Deposition Date: 2017/6/15
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.89  Å
Source Organism:
Similar Structures:
Biological Unit for 5W5O: dimeric; determined by author and by software (PISA)
Molecular Components in 5W5O
Label Count Molecule
Proteins (2 molecules)
2
Receptor-interacting Serine/threonine-protein Kinase 2
(Gene symbol: RIPK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303