5VWM: Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor

PDB ID: 5VWMDownload
MMDB ID: 151619
PDB Deposition Date: 2017/5/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5VWM: monomeric; determined by author and by software (PISA)
Molecular Components in 5VWM
Label Count Molecule
Protein (1 molecule)
1
Udp-3-o-acyl-n-acetylglucosamine Deacetylase
(Gene symbol: lpxC)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamideN-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide
2
1
ZINC IONZINC ION
3
1
CHLORIDE IONCHLORIDE ION
4
1
CALCIUM IONCALCIUM ION
5
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303