5VP9: Crystal structure of HCV NS3/4A protease in complex with AM-07, an analogue of 5172-mcP1P3

PDB ID: 5VP9Download
MMDB ID: 152039
PDB Deposition Date: 2017/5/4
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.859  Å
Source Organism:
Similar Structures:
Biological Unit for 5VP9: monomeric; determined by author and by software (PISA)
Molecular Components in 5VP9
Label Count Molecule
Protein (1 molecule)
1
Ns4a Cofactor -- NS3 Protein Chimera
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
tert-butyl [(2R,6S,12Z,13aS,14aR,16aS)-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-2-{[3-(thiophen-2-yl)quinoxalin-2-yl]oxy}-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamatetert-butyl [(2R,6S,12Z,13aS,14aR,16aS)-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-2-{[3-(thiophen-2-yl)quinoxalin-2-yl]oxy}-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate
2
1
SULFATE IONSULFATE ION
3
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303