5VAD: Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor

PDB ID: 5VADDownload
MMDB ID: 151397
PDB Deposition Date: 2017/3/24
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.36  Å
Source Organism:
Similar Structures:
Biological Unit for 5VAD: dimeric; determined by author and by software (PISA)
Molecular Components in 5VAD
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Glutamate/proline--trna Ligase
(Gene symbol: EPRS1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide
2
2
PROLINEPROLINE
3
2
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303