5V9T: Crystal structure of selective pyrrolidine amide KDM5a inhibitor N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide (compound 48)

PDB ID: 5V9TDownload
MMDB ID: 150742
PDB Deposition Date: 2017/3/23
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 3.05  Å
Source Organism:
Similar Structures:
Biological Unit for 5V9T: dimeric; determined by author and by software (PISA)
Molecular Components in 5V9T
Label Count Molecule
Proteins (2 molecules)
1
Lysine-specific Demethylase 5A
(Gene symbol: KDM5A)
Molecule annotation
1
Lysine-specific Demethylase 5A
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
NICKEL (II) IONNICKEL (II) ION
2
2
ZINC IONZINC ION
3
1
N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamideN-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303