5V9P: Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A

PDB ID: 5V9PDownload
MMDB ID: 150741
PDB Deposition Date: 2017/3/23
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 5V9P: dimeric; determined by author and by software (PISA)
Molecular Components in 5V9P
Label Count Molecule
Proteins (2 molecules)
1
Lysine-specific Demethylase 5A
(Gene symbol: KDM5A)
Molecule annotation
1
Lysine-specific Demethylase 5A
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
NICKEL (II) IONNICKEL (II) ION
2
2
ZINC IONZINC ION
3
1
[(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone[(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone
4
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303