5V6S: Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C

PDB ID: 5V6SDownload
MMDB ID: 152265
PDB Deposition Date: 2017/3/17
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5V6S: monomeric; determined by author and by software (PISA)
Molecular Components in 5V6S
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303