5UVC: Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

PDB ID: 5UVCDownload
MMDB ID: 153039
PDB Deposition Date: 2017/2/20
Updated in MMDB: 2017/09
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 5UVC: monomeric; determined by author and by software (PISA)
Molecular Components in 5UVC
Label Count Molecule
Protein (1 molecule)
1
Beta-adrenergic Receptor Kinase 1
(Gene symbol: GRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
N-benzyl-3-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)benzamideN-benzyl-3-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)benzamide
2
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303