5UUU: Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

PDB ID: 5UUUDownload
MMDB ID: 153038
PDB Deposition Date: 2017/2/17
Updated in MMDB: 2017/09
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5UUU: monomeric; determined by author and by software (PISA)
Molecular Components in 5UUU
Label Count Molecule
Protein (1 molecule)
1
Beta-adrenergic Receptor Kinase 1
(Gene symbol: GRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide
2
2
SULFATE IONSULFATE ION
3
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303