5UOV: HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group

PDB ID: 5UOVDownload
MMDB ID: 150712
PDB Deposition Date: 2017/2/1
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.33  Å
Source Organism:
Similar Structures:
Biological Unit for 5UOV: dimeric; determined by author and by software (PISA)
Molecular Components in 5UOV
Label Count Molecule
Proteins (2 molecules)
2
Protease
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
N-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3-[(2R)-2-(4-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carbonyl]benzamideN-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3-[(2R)-2-(4-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carbonyl]benzamide
2
1
SODIUM IONSODIUM ION
3
3
CHLORIDE IONCHLORIDE ION
4
1
GLYCEROLGLYCEROL
5
1
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303