5U7M: Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom

PDB ID: 5U7MDownload
MMDB ID: 154138
PDB Deposition Date: 2016/12/12
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 3.025  Å
Source Organism:
Human immunodeficiency virus 1▼
Similar Structures:
Biological Unit for 5U7M: hexameric; determined by author
Molecular Components in 5U7M
Label Count Molecule
Proteins (6 molecules)
1
Envelope Glycoprotein Gp160
Molecule annotation
1
35o22 FAB Heavy Chain
Molecule annotation
1
35o22 FAB Light Chain
Molecule annotation
1
Envelope Glycoprotein Gp160
Molecule annotation
1
Pgt122 FAB Heavy Chain
Molecule annotation
1
Pgt122 FAB Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (63 molecules)
1
35
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
6
beta-D-mannopyranosebeta-D-mannopyranose
3
16
alpha-D-mannopyranosealpha-D-mannopyranose
4
5
SULFATE IONSULFATE ION
5
1
1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303