5U1W: Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120

PDB ID: 5U1WDownload
MMDB ID: 146136
PDB Deposition Date: 2016/11/29
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.501  Å
Source Organism:
Similar Structures:
Biological Unit for 5U1W: trimeric; determined by author and by software (PISA)
Molecular Components in 5U1W
Label Count Molecule
Proteins (3 molecules)
3
P2X Purinoceptor
(Gene symbol: P2RX7)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]-2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]acetamideN-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]-2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303