5TZR: GPR40 in complex with partial agonist MK-8666

PDB ID: 5TZRDownload
MMDB ID: 151573
PDB Deposition Date: 2016/11/22
Updated in MMDB: 2018/12
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 5TZR: monomeric; determined by author and by software (PISA)
Molecular Components in 5TZR
Label Count Molecule
Protein (1 molecule)
1
Free Fatty Acid Receptor 1,endolysin,free Fatty Acid Receptor 1
(Gene symbol: FFAR1)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
SODIUM IONSODIUM ION
2
1
(5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid(5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid
3
1
MALONATE IONMALONATE ION
4
8
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
5
2
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303