5TRU: Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4

PDB ID: 5TRUDownload
MMDB ID: 150690
PDB Deposition Date: 2016/10/27
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Molecular Components in 5TRU
Label Count Molecule
Proteins (6 molecules)
2
Ipilimumab FAB Light Chain
Molecule annotation
2
Ipilimumab FAB Heavy Chain
Molecule annotation
2
Cytotoxic T-lymphocyte Protein 4
(Gene symbol: CTLA4)
Molecule annotation
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303