5TQ3: Design and Synthesis of a pan-JAK kinase inhibitor clinical candidate (PF-06263276) suitable for the treatment of inflammatory diseases of the lungs and skin

PDB ID: 5TQ3Download
MMDB ID: 146362
PDB Deposition Date: 2016/10/23
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.69  Å
Source Organism:
Similar Structures:
Biological Unit for 5TQ3: monomeric; determined by author and by software (PISA)
Molecular Components in 5TQ3
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303