5TPG: Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors

PDB ID: 5TPGDownload
MMDB ID: 146842
PDB Deposition Date: 2016/10/20
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 5TPG: monomeric; determined by author and by software (PISA)
Molecular Components in 5TPG
Label Count Molecule
Protein (1 molecule)
1
Tryptophan 5-hydroxylase 1
(Gene symbol: TPH1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
FE (III) IONFE (III) ION
2
1
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
3
2
ACETONITRILEACETONITRILE
4
1
(3S)-8-(2-amino-6-{(1R)-1-[5-chloro-3'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid(3S)-8-(2-amino-6-{(1R)-1-[5-chloro-3'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303