5TLF: Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Constrained WAY Derivative, 4-(2-(3-methylbut-2-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl)benzene-1,3-diol

PDB ID: 5TLFDownload
MMDB ID: 146617
PDB Deposition Date: 2016/10/11
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.204  Å
Source Organism:
Similar Structures:
Biological Unit for 5TLF: tetrameric; determined by author and by software (PISA)
Molecular Components in 5TLF
Label Count Molecule
Proteins (4 molecules)
2
Estrogen Receptor
(Gene symbol: ESR1)
Molecule annotation
2
Nuclear Receptor Coactivator 2
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
4-[2-(3-methylbut-2-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol4-[2-(3-methylbut-2-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303