5TD2: Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate

PDB ID: 5TD2Download
MMDB ID: 146835
PDB Deposition Date: 2016/9/16
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 2.68  Å
Source Organism:
Similar Structures:
Biological Unit for 5TD2: monomeric; determined by author and by software (PISA)
Molecular Components in 5TD2
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase MER
(Gene symbol: MERTK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamideN-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303