5TC8: Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A

PDB ID: 5TC8Download
MMDB ID: 155544
PDB Deposition Date: 2016/9/14
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5TC8: trimeric; determined by author and by software (PISA)
Molecular Components in 5TC8
Label Count Molecule
Proteins (3 molecules)
3
S-methyl-5'-thioadenosine Phosphorylase
(Gene symbol: MTAP)
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
3
(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL
2
3
PHOSPHATE IONPHOSPHATE ION
3
1
MAGNESIUM IONMAGNESIUM ION
4
1
CHLORIDE IONCHLORIDE ION
5
3
NONAETHYLENE GLYCOLNONAETHYLENE GLYCOL
6
6
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303