5TBH: Crystal structure of mouse CARM1 in complex with inhibitor LH1236

PDB ID: 5TBHDownload
MMDB ID: 154633
PDB Deposition Date: 2016/9/12
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 2.341  Å
Source Organism:
Similar Structures:
Biological Unit for 5TBH: tetrameric; determined by software (PISA)
Molecular Components in 5TBH
Label Count Molecule
Proteins (4 molecules)
4
Histone-arginine Methyltransferase Carm1
(Gene symbol: Carm1)
Molecule annotation
Chemicals and Non-standard biopolymers (23 molecules)
1
1
1-METHOXY-2-(2-METHOXYETHOXY)ETHANE1-METHOXY-2-(2-METHOXYETHOXY)ETHANE
2
17
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
4
2
5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine
5
2
(2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid(2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303