5T1A: Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

PDB ID: 5T1ADownload
MMDB ID: 145675
PDB Deposition Date: 2016/8/18
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.806  Å
Source Organism:
Similar Structures:
Biological Unit for 5T1A: monomeric; determined by author and by software (PISA)
Molecular Components in 5T1A
Label Count Molecule
Protein (1 molecule)
1
Chimera Protein of CC Chemokine Receptor Type 2 Isoform B and T4-lysozyme,lysozyme
(Gene symbol: CCR2)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
(3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one(3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one
2
1
(2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one(2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one
3
4
SULFATE IONSULFATE ION
4
1
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
5
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303