5T0L: Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15)

PDB ID: 5T0LDownload
MMDB ID: 143615
PDB Deposition Date: 2016/8/16
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 3.13  Å
Source Organism:
Similar Structures:
Biological Unit for 5T0L: dimeric; determined by author and by software (PISA)
Molecular Components in 5T0L
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
2
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
2
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
4
2
5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303