5SWP: Crystal Structure of PI3Kalpha in complex with fragments 6 and 24

PDB ID: 5SWPDownload
MMDB ID: 182242
PDB Deposition Date: 2016/8/8
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 3.41  Å
Source Organism:
Similar Structures:
Biological Unit for 5SWP: dimeric; determined by author and by software (PISA)
Molecular Components in 5SWP
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
tert-butyl 4-aminopiperidine-1-carboxylatetert-butyl 4-aminopiperidine-1-carboxylate
2
2
2-methylcyclohexane-1,3-dione2-methylcyclohexane-1,3-dione
3
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303