5SW8: Crystal structure of PI3Kalpha in complex with fragments 7 and 11

PDB ID: 5SW8Download
MMDB ID: 147363
PDB Deposition Date: 2016/8/8
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 5SW8: dimeric; determined by author and by software (PISA)
Molecular Components in 5SW8
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
2
1
2H-indazol-5-amine2H-indazol-5-amine
3
2
2-CHLOROBENZENESULFONAMIDE2-CHLOROBENZENESULFONAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303