5SGO: CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n1cnc(c2c1scc2c3ccc(cc3)F)OCCCOc4cc(ccc4)NC(=O)C, micromolar IC50=0.012

PDB ID: 5SGODownload
MMDB ID: 253859
PDB Deposition Date: 2022/2/1
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 5SGO: monomeric; determined by author
Molecular Components in 5SGO
Label Count Molecule
Protein (1 molecule)
1
Camp and Camp-inhibited Cgmp 3',5'-cyclic Phosphodiesterase 10A
(Gene symbol: PDE10A)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
ZINC IONZINC ION
2
1
N-[3-(3-{[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}propoxy)phenyl]acetamideN-[3-(3-{[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}propoxy)phenyl]acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303