5PAM: Crystal Structure of Factor VIIa in complex with 2-[(1-aminoisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluorophenyl)-1-(2-phenylpyrrolidin-1-yl)ethanone

PDB ID: 5PAMDownload
MMDB ID: 151974
PDB Deposition Date: 2016/11/10
Updated in MMDB: 2021/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5PAM: dimeric; determined by author
Molecular Components in 5PAM
Label Count Molecule
Proteins (2 molecules)
1
Coagulation Factor VII Light Chain
(Gene symbol: F7)
Molecule annotation
1
Coagulation Factor VII Heavy Chain
(Gene symbol: F7)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
3
CHLORIDE IONCHLORIDE ION
2
2
GLYCEROLGLYCEROL
3
1
CALCIUM IONCALCIUM ION
4
1
SULFATE IONSULFATE ION
5
1
(2~{R})-2-[(1-azanylisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluoranyl-phenyl)-1-[(2~{R})-2-phenylpyrrolidin-1-yl]ethanone(2~{R})-2-[(1-azanylisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluoranyl-phenyl)-1-[(2~{R})-2-phenylpyrrolidin-1-yl]ethanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303