5O7A: Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin

PDB ID: 5O7ADownload
MMDB ID: 152430
PDB Deposition Date: 2017/6/8
Updated in MMDB: 2017/07
Experimental Method:
x-ray diffraction
Resolution: 2.495  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 5O7A: hexameric; determined by author and by software (PISA)
Molecular Components in 5O7A
Label Count Molecule
Proteins (6 molecules)
2
Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta-2b Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
1
Uncharacterized Protein
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
3
4
MAGNESIUM IONMAGNESIUM ION
4
2
(2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide(2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide
5
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303