5NTW: Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

PDB ID: 5NTWDownload
MMDB ID: 151959
PDB Deposition Date: 2017/4/28
Updated in MMDB: 2017/07
Experimental Method:
x-ray diffraction
Resolution: 1.64  Å
Source Organism:
Similar Structures:
Biological Unit for 5NTW: dimeric; determined by author and by software (PISA)
Molecular Components in 5NTW
Label Count Molecule
Proteins (2 molecules)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
1
Nuclear Receptor-interacting Protein 1
(Gene symbol: NRIP1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-isopropyl-6-(((1r,4S)-4-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide(S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-isopropyl-6-(((1r,4S)-4-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303