5NN8: Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose

PDB ID: 5NN8Download
MMDB ID: 155327
PDB Deposition Date: 2017/4/8
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 5NN8: monomeric; determined by software (PISA)
Molecular Components in 5NN8
Label Count Molecule
Protein (1 molecule)
1
Lysosomal Alpha-glucosidase
(Gene symbol: GAA)
Molecule annotation
Chemicals and Non-standard biopolymers (42 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
alpha-L-fucopyranosealpha-L-fucopyranose
3
2
beta-D-mannopyranosebeta-D-mannopyranose
4
3
alpha-D-glucopyranosealpha-D-glucopyranose
5
2
4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose
6
3
SULFATE IONSULFATE ION
7
3
CHLORIDE IONCHLORIDE ION
8
15
1,2-ETHANEDIOL1,2-ETHANEDIOL
9
1
GLYCEROLGLYCEROL
10
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303