5NJH: Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin

PDB ID: 5NJHDownload
MMDB ID: 151951
PDB Deposition Date: 2017/3/28
Updated in MMDB: 2017/07
Experimental Method:
x-ray diffraction
Resolution: 2.394  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 5NJH: hexameric; determined by software (PISA)
Molecular Components in 5NJH
Label Count Molecule
Proteins (6 molecules)
2
Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta-2b Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
1
Tubulin Tyrosine Ligase TTL
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
5
MAGNESIUM IONMAGNESIUM ION
3
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
4
1
5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine
5
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303