5MAT: Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor

PDB ID: 5MATDownload
MMDB ID: 147162
PDB Deposition Date: 2016/11/4
Updated in MMDB: 2018/06
Experimental Method:
x-ray diffraction
Resolution: 2.069  Å
Source Organism:
Similar Structures:
Biological Unit for 5MAT: dimeric; determined by author and by software (PISA)
Molecular Components in 5MAT
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
2
ZINC IONZINC ION
2
1
(7~{R})-7-[(3,5-dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one(7~{R})-7-[(3,5-dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
3
14
SULFATE IONSULFATE ION
4
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
5
1
HEXAETHYLENE GLYCOLHEXAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303