5MAR: Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose

PDB ID: 5MARDownload
MMDB ID: 148105
PDB Deposition Date: 2016/11/4
Updated in MMDB: 2018/06
Experimental Method:
x-ray diffraction
Resolution: 1.89  Å
Source Organism:
Similar Structures:
Biological Unit for 5MAR: monomeric; determined by author and by software (PISA)
Molecular Components in 5MAR
Label Count Molecule
Protein (1 molecule)
1
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
1
ZINC IONZINC ION
2
2
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
3
2
3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]propan-1-ol3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]propan-1-ol
4
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
6
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
6
3
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303