5M96: Synthesis and biological evaluation of new triazolo and imidazolopyridine RORgt inverse agonists

PDB ID: 5M96Download
MMDB ID: 145663
PDB Deposition Date: 2016/10/31
Updated in MMDB: 2018/12
Experimental Method:
x-ray diffraction
Resolution: 1.77  Å
Source Organism:
Similar Structures:
Biological Unit for 5M96: monomeric; determined by author
Molecular Components in 5M96
Label Count Molecule
Protein (1 molecule)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
3
~{N}-[8-[[(3~{S})-4-cyclopentylcarbonyl-3-methyl-piperazin-1-yl]methyl]-7-methyl-imidazo[1,2-a]pyridin-6-yl]-2-methyl-pyrimidine-5-carboxamide~{N}-[8-[[(3~{S})-4-cyclopentylcarbonyl-3-methyl-piperazin-1-yl]methyl]-7-methyl-imidazo[1,2-a]pyridin-6-yl]-2-methyl-pyrimidine-5-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303